Manchester City captain Vincent Kompany won’t be involved after suffering a groin injury during the defeat by Real Madrid on Wednesday.
David Silva, Pablo Zabaleta and Aleksandar Kolarov have also been ruled out because of injury.
Arsenal midfielder Alex Oxlade-Chamberlain will miss the rest of the season and Euro 2016 after suffering his second knee injury of the campaign.
Per Mertesacker is out for the next two matches with a hamstring problem.