West Ham are without a recognised left-back after Arthur Masuaku joined Aaron Cresswell on the sidelines with a knee injury.
Central defender Winston Reid will return, but Andre Ayew, Andy Carroll and Diafra Sakho remain out.
Southampton boss Claude Puel is expected to hand a start to Charlie Austin, who has scored four goals in his last three matches.
Fellow striker Jay Rodriguez is out with a groin problem.
West Ham have only failed to score in one of their 14 home Premier League meetings with Southampton: a 1-0 defeat in December 2002.
The team scoring first has gone on to lose this fixture at West Ham in each of the last three seasons, with the Hammers coming from behind twice.
Editor’s Note: This copy and paste will have to do, I am so hungover