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Tottenham midfielder Mousa Dembele has been banned for six matches after being found guilty of violent conduct for an incident during the draw with Chelsea.
Dele Alli is already suspended, while fellow midfielder Nabil Bentaleb remains out with a knee injury.
Southampton manager Ronald Koeman could name an unchanged side after their 4-2 win over Manchester City last weekend.
Out-of-favour striker Graziano Pelle was dropped from the last squad but could be involved against Tottenham.
