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Having a therapy that has been shown metformin overdose to address multiple symptoms of Rett syndrome provides a promising treatment option that may lead to meaningful impact for patients and their families. The most common adverse reactions reported with trofinetide led metformin overdose to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints). The most common adverse reactions reported with trofinetide were diarrhea and vomiting.

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