Tottenham quartet Son Heung-min, Ryan Mason, Nabil Bentaleb and Alex Pritchard are ruled out with injuries.
Eric Dier serves a one-game ban after accumulating five yellow cards but Danny Rose returns from a hand injury.
Liverpool pair Joe Gomez and Danny Ings have both suffered anterior cruciate ligament injuries and could miss the rest of the season.
Christian Benteke, Jordan Henderson and Roberto Firmino are all sidelined by injuries but Philippe Coutinho is fit.
Dejan Lovren has returned to training following an ankle injury.
Editor’s Note: Obviously all the focus will be on Jurgen Klopp today as he takes charge of Liverpool for the first time. As for the game itself, I think it’s a tough one to call. Tottenham haven’t lost in 7 whereas Liverpool will no doubt be looking to get Jurgen Klopp’s reign off to the perfect start. Both teams are lacking key forwards so it will be interesting to see where the goals come from. I think it will be a low scoring draw today, I’m going to stick my neck on the block and say 1-1.